Institute for Systems Biology
Public records show a registered, tax-exempt organization in good standing.
What it says it does
NON-PROFIT RESEARCH INSTITUTE TO ADVANCE A SYSTEMS (OR HOLISTIC AND CROSS-DISCIPLINARY) APPROACH TO SCIENCE; PERSONALIZED MEDICINE; GLOBAL HEALTH & ENVIRONMENTAL SUSTAINABILITY; SCIENCE EDUCATION; & THE PIONEERING & INVENTION OF BIOLOGICAL & TECHNOLOGICAL METHODS & TOOLS.
- Income
- $42.3 million
- Spending
- $47.6 million
- Spent on programs
- 71%
- Reserves
- 9.4 months of spending
- Largest source of income
- government grants, 55%
- Employees
- 299
- Volunteers
- 22
- Highest pay
- $3.2 million, director - thru 3/24
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Financial health
Fair: 67 out of 100. Higher than 39% of charities in its peer group (science, $10m to $100m).
Reserves
28 of 35Spendable reserves would cover 9.4 months of spending.
Debt
10 of 20It owes 46% of what it owns.
Living within its means
4 of 15Spending exceeded income by 13% of income.
Income trend
10 of 15Income fell 3% on the year before.
Spending floor
15 of 1571% of spending went to programs and raising each dollar of donations cost 1 cents.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Governance
Strong: 100 out of 100. Higher than 49% of charities in its peer group (science, $10m to $100m).
Independent board
25 of 2512 of 16 voting board members are independent.
Conflict of interest policy
15 of 15Has a written conflict of interest policy.
Whistleblower policy
8 of 8Has a written whistleblower policy.
Record keeping policy
7 of 7Has a written policy on keeping and destroying records.
Board minutes
5 of 5Keeps minutes of board meetings.
Board sees the tax return
10 of 10Gave the board a copy of this return before filing it.
Pay set independently
5 of 5Sets its chief executive's pay through independent review and comparison.
Independent check of accounts
15 of 15Its accounts were audited by an independent accountant.
No reported misuse
10 of 10Reports no diversion of assets, excess benefits or loans to insiders.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Impact evidence
Describes programs. Its tax return describes what it does but we have found no measurable results in it.
Programs described in its return (1)
- $33.8 million spent. SEE SCHEDULE OAT PROVIDENCE, WE USE OUR VOICE TO ADVOCATE FOR VULNERABLE POPULATIONS AND NEEDED REFORMS IN HEALTH CARE. WE ARE ALSO PURSUING INNOVATIVE WAYS TO TRANSFORM HEALTH CARE BY KEEPING PEOPLE HEALTHY, AND MAKING OUR SERVICES MORE CONVENIENT, ACCESSIBLE AND AFFORDABLE FOR ALL. IN AN INCREASINGLY UNCERTAIN WORLD, WE ARE COMMITTED TO HIGH-QUALITY, COMPASSIONATE HEALTH CARE FOR EVERYONE - REGARDLESS OF COVERAGE OR ABILITY TO PAY. WE HELP PEOPLE AND COMMUNITIES BENEFIT FROM THE BEST HEALTH CARE MODEL FOR THE FUTURE - TODAY.TOGETHER, OUR 125,000 CAREGIVERS (ALL EMPLOYEES) SERVE IN 51 HOSPITALS, 1,014 CLINICS AND A COMPREHENSIVE RANGE OF HEALTH AND SOCIAL SERVICES ACROSS ALASKA, CALIFORNIA, MONTANA, NEW MEXICO, OREGON, TEXAS AND WASHINGTON. THE PROVIDENCE AFFILIATE FAMILY INCLUDES:-PROVIDENCE ACROSS FIVE WESTERN STATES-COVENANT HEALTH IN WEST TEXAS AND NEW MEXICO-FACEY MEDICAL GROUP IN LOS ANGELES, CA-KADLEC IN SOUTHEAST WASHINGTON-PACIFIC MEDICAL CENTERS IN SEATTLE, WA-SWEDISH HEALTH SERVICES IN SEATTLE, WAIN 2024, PROVIDENCE MINISTRIES AND AFFILIATES PROVIDED $1.9 BILLION IN COMMUNITY BENEFIT PROGRAMS. THIS INCLUDES FREE AND DISCOUNTED CARE, UNCOMPENSATED AND SUBSIDIZED CARE, AND OTHER COMMUNITY HEALTH ACTIVITIES.ONE OF THESE VITAL PROGRAMS, MEDICAID, IS A LIFELINE FOR MILLIONS OF INDIVIDUALS, INCLUDING SENIORS, CHILDREN, PREGNANT PATIENTS, THOSE WITH DISABILITIES AND VETERANS. WE ARE GRATEFUL TO EVERYONE IN OUR COMMUNITIES WHO HAS JOINED US IN ADVOCATING FOR CONTINUED FUNDING AND EXPANSION OF THIS PROGRAM. TOGETHER, WE ARE HELPING TO ENSURE MORE PEOPLE HAVE ACCESS TO NEEDED CARE.FOR MORE INFORMATION GO TO: HTTPS://WWW.PROVIDENCE.ORG/ABOUT/ANNUAL-REPORTTHROUGH OUR COMMUNITY BENEFIT PROGRAMS, WE FOCUS ON MEETING THE DIVERSE NEEDS OF THE PEOPLE WE SERVE BY WORKING TO ENSURE BASIC HEALTH NEEDS ARE MET, REMOVING BARRIERS TO CARE, BUILDING COMMUNITY RESILIENCE AND INNOVATING FOR THE FUTURE. PROVIDENCE CONTINUES TO WORK TOWARDS CARBON NEGATIVE AND IN 2024 DECREASED EMISSIONS BY 19 PERCENT COMPARED TO OUR 2019 BASELINE. OUR EFFORTS EARNED US A SYSTEM RECORD 55 ENVIRONMENTAL EXCELLENCE AWARDS FROM PRACTICE GREENHEALTH AND MADE US THE FIRST LARGE SYSTEM TO RECEIVE THE JOINT COMMISSION'S SUSTAINABLE HEALTHCARE CERTIFICATION IN 2024 FOR EACH OF OUR HOSPITALS.PROGRAM SERVICE ACCOMPLISHMENTSBIOMOLECULAR RESEARCH: IN 2024, ISB RESEARCHERS PUBLISHED 131 ACADEMIC RESEARCH PAPERS IN A RANGE OF HIGH-PROFILE JOURNALS. TOPICS COVERED INCLUDED COVID-19, GENOMICS, MICROFLUIDICS, PROTEOMICS, HIGH-THROUGHPUT COMPUTATION, MULTISCALE MODELING, SYSTEMS BIOLOGY APPLICATIONS, BIOINFORMATICS, GLOBAL HEALTH, AND CANCERS.ISB EDUCATION & OUTREACHISB EDUCATION'S PROGRAM ACTIVITIES REPORTED FOR THE 2024/25 SCHOOL YEAR ARE LISTED BELOW IN FIVE CATEGORIES.OUR VISION IS THAT STUDENTS GRADUATE READY TO LEARN, THRIVE, WORK AND ENGAGE IN A STEM-RICH SOCIETY. WE WANT EVERY STUDENT TO HAVE AN OPPORTUNITY TO DO REAL SCIENCE WE BRING CURRENT SCIENCE AND AUTHENTIC PRACTICES TO SCHOOLS.1- COMBINED ACTIVITIES ACROSS TWO ISB EDUCATION GROUPSPARTNERS AND FUNDERS:-12 MONTHLY IMPACT STORIES WERE WRITTEN BY THE ISB EDUCATION TEAM TO COMMUNICATE REGULARLY WITH PARTNERS AND FUNDERS. HTTPS://ISBSCIENCE.ORG/NEWS/EDUCATION/2024-25-SCHOOL-YEAR-ISB-EDUCATION-HIGHLIGHTS/-10 PARTNERSHIPS CONTINUES, WITH REGIONAL SCHOOL DISTRICTS AND OTHER NON-PROFIT ORGANIZATIONS-7 PRESENTATIONS WERE GIVEN AT EVENTS FOR REGIONAL, STATE, AND NATIONAL AUDIENCES.SCHOOL SYSTEMS: "CLIMETIME" HTTPS://WWW.CLIMETIME.ORG/CBO-GRANTEES/ISB/-4 WORKSHOP SERIES WERE PROVIDED FOR ELEMENTARY AND SECONDARY SCIENCE TEACHERS.-93 EDUCATORS, ACROSS THE RANGE OF GRADES: ELEMENTARYMIDDLE-AND HIGH SCHOOL.-35 SCHOOL DISTRICTS HAD EDUCATORS PARTICIPATING IN THE EVENTS.-8 EDUCATIONAL SERVICE DISTRICT REGIONS ACROSS WA STATE HAD EDUCATORS PARTICIPATING IN THE EVENTS.STEM PROFESSIONALS:-50+ STEM PROFESSIONALS CONTRIBUTED TO THE ABOVE EDUCATION ACTIVITIES, TO SUPPORT LEARNING EXPERIENCES FOR STUDENTS, TEACHERS, AND PRINCIPALS.2- BALIGA LAB'S SYSTEMS EDUCATION EXPERIENCES K-12 STUDENT-TEACHER-SCIENTIST PARTNERSHIPS HTTPS://SEE.ISBSCIENCE.ORG/STUDENTS:-181 TOTAL: HIGH SCHOOL STUDENTS-SYSTEMS THINKERS IN STEM AMBASSADORS-RESEARCH INTERNS-WANIC COURSE-"ENVIRONMENTAL IN THE OUTDOORS RESEARCH EXPERIENCE" (ESORE)-LEADERSHIP, EMPOWERMENT, AND DEVELOPMENT IN STEMAMERICORPS MEMBERS:-2 AMERICORPS MEMBERS LEADING "SUPPORT SYSTEM FOR ISB'S INTERNS AND "WRAP AROUND STUDENT SUPPORT"TO ADDRESS ONGOING STUDENT NEEDS.TEACHERS:-3 TEACHER INTERNS-2 STAR FELLOWSSEE-RESOURCES FOR CLASSROOMS:-4 TEACHERS IN 4 DIFFERENT SCHOOLS IMPLEMENTING "SYSTEMS MEDICINE"(NEW CTE COURSE COMPRISED OF 4 DRAFT CURRICULUM MODULES)-3 ADDITIONAL CURRICULUM MODULES IN DEVELOPMENT, "CARBON'S FATE", "MICROPLASTICS", "RULES OF LIFE" WHICH HAS THREE SUB-SECTIONS.3- LOGAN CENTER FOR EDUCATION K-12 SCHOOL DISTRICT PARTNERSHIPS + STATE LEADERS PARTNERSHIP HTTPS:/LOGANCENTER.ISBSCIENCE.ORG/WHOLE SCHOOL SYSTEMS: WE CONTINUED PARTNERSHIPS SCHOOL DISTRICTS ACROSS THE PUGET SOUND REGION ON THEIR K-12 SCIENCE/STEM PROGRAMS.-24 HIGH SCHOOL SCIENCE TEACHERS (ALL OF THEM) WERE SUPPORTED IN YEAR 2 OF A 5-YEAR PARTNERSHIP WITH CENTRAL KITSAP SCHOOL DISTRICT.-12 SCHOOL AND DISTRICT-LEVEL ADMINISTRATORS FROM 5 SCHOOL DISTRICTS PARTICIPATED IN A 6 PART COURSE "PRINCIPLES OF SCIENCE FOR PRINCIPALS."-5 DISTRICT LEADERS PARTICIPATED IN THE "SECONDARY STEM PROJECT" MONTHLY LEADERSHIP TEAM PLANNING SESSIONS.DISTRICT SCIENCE LEADERS:-9 REGIONAL DIRECTORS: AS CO-DIRECTOR OF WASHINGTON STATE LASER, WE PROVIDED MONTHLY PROFESSIONAL GROWTH SESSIONS FOR SCIENCE LEADERS, COVERING ALL WA SCHOOL DISTRICTS.-22 SCHOOL DISTRICT SCIENCE/STEM LEADERS: AS DIRECTOR OF PUGET SOUND LASER ALLIANCE, 1 OF THE 9 REGIONS, WE PROVIDED MONTHLY PROFESSIONAL GROWTH SESSIONS FOR SCIENCE LEADERS OF THIS COLLABORATIVE ACROSS KING AND PIERCE COUNTIES; 22 OF 36 DISTRICTS PARTICIPATED.4- POST-SECONDARY SCIENCE EDUCATIONCOMMUNITY COLLEGES: "NEXT-GEN BIOLOGY LEARNING NETWORK"-35 COMMUNITY AND TE
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Legitimacy checks
Is it registered with the IRS? Passed.
Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.
Has the IRS revoked its tax-exempt status? Passed.
Not on the IRS automatic revocation list.
Source: Automatic revocation of exemption list, Internal Revenue Service, file dated November 6, 2026.
Are donations tax-deductible? Passed.
On the IRS list of organizations eligible to receive tax-deductible contributions.
Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated October 13, 2026.
Is it keeping up with its IRS filings? Passed.
Most recent return on file covers the year ending December 2024.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.
How long has it been tax-exempt? Passed.
Recognized by the IRS since March 2000.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.
Is it in good standing with state regulators? Passed.
Not on California's list of charities barred from soliciting. Other states are not yet checked.
Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated November 4, 2026.
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