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Pacific Northwest Research Institute

EIN 91-0667886 · Seattle, WA

Public records show a registered, tax-exempt organization in good standing.

LegitimacyPassesRegistration and standingFinancial healthFair55 out of 100GovernanceStrong90 out of 100Impact evidenceDescribes programsHow well its results are evidenced

What it says it does

PACIFIC NORTHWEST RESEARCH INSTITUTE (PNRI), A NONPROFIT CORPORATION, IS AN INDEPENDENT, BIOMEDICAL RESEARCH INSTITUTE CONDUCTING BASIC AND APPLIED RESEARCH AIMED AT UNDERSTANDING HOW HEALTH IS MAINTAINED IN THE FACE OF GENETIC AND ENVIRONMENTAL RISKS ASSOCIATED WITH DISEASE DEVELOPMENT. THE SCIENTIFIC DISCOVERIES HAVE APPLICABILITY IN A VARIETY OF DISEASES, INCLUDING DIABETES, CANCER, NEUROLOGICAL DISORDERS, AMONG MANY OTHERS.

Income
$5.5 million
Spending
$10.9 million
Spent on programs
81%
Reserves
2.1 months of spending
Largest source of income
government grants, 65%
Employees
95
Volunteers
9
Highest pay
$401,797, ceo thru 12/23

Source: Form 990 for the year ending September 30, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Financial health

Fair: 55 out of 100. Higher than 15% of charities in its peer group (medical research, $1m to $10m).

  • Reserves

    10 of 35

    Spendable reserves would cover 2.1 months of spending.

  • Debt

    20 of 20

    It owes 7% of what it owns.

  • Living within its means

    0 of 15

    Spending exceeded income by 99% of income.

  • Income trend

    10 of 15

    Income fell 3% on the year before.

  • Spending floor

    15 of 15

    81% of spending went to programs and raising each dollar of donations cost 4 cents.

Source: Form 990 for the year ending September 30, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Governance

Strong: 90 out of 100. Higher than 49% of charities in its peer group (medical research, $1m to $10m).

  • Independent board

    25 of 25

    9 of 9 voting board members are independent.

  • Conflict of interest policy

    15 of 15

    Has a written conflict of interest policy.

  • Whistleblower policy

    8 of 8

    Has a written whistleblower policy.

  • Record keeping policy

    7 of 7

    Has a written policy on keeping and destroying records.

  • Board minutes

    5 of 5

    Keeps minutes of board meetings.

  • Board sees the tax return

    0 of 10

    Did not give the board a copy of this return before filing it.

  • Pay set independently

    5 of 5

    Sets its chief executive's pay through independent review and comparison.

  • Independent check of accounts

    15 of 15

    Its accounts were audited by an independent accountant.

  • No reported misuse

    10 of 10

    Reports no diversion of assets, excess benefits or loans to insiders.

Source: Form 990 for the year ending September 30, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Impact evidence

Describes programs. Its tax return describes what it does but we have found no measurable results in it.

Programs described in its return (4)
  1. $5.1 million spent. THE STUBBS LAB IS FOCUSED ON UNDERSTANDING HOW THE INTERPLAY BETWEEN GENES AND ENVIRONMENT SHAPES BRAIN DEVELOPMENT, AND HOW THAT INTERPLAY ULTIMATELY INFLUENCES BEHAVIOR. WE STUDY THE FOLE OF GENE REGULATION, THE PROCESSES RESPONSIBLE FOR ORCHESTRATING HOW GENES ARE USED IN EACH BRAIN CELL TO SPECIFY UNIQUE FUNCTIONS AND HOW WHAT HAPPENS DURING OUR LIFETIME LEADS TO CHANGES IN THOSE PROCESSES.
  2. $1.3 million spent. EXPERIMENTING IN YEAST ALLOWS THE DUDLEY LAB TO MAKE DISCOVERIES THAT GO BEYOND THE LAB WITH THE POWER TO CHANGE HOW SCIENTISTS AROUND THE GLOBE APPROACH GENETIC RESEARCH. FROM PERFORMING LARGESCALE EXPERIMENTS TO DISCOVERING NEW ANTIFUNGAL TREATMENTS, THE DUDLEY LAB IS A WORLD LEADER IN USING YEAST TO ANSWER FUNDAMENTAL QUESTIONS ABOUT BIOLOGY. WE ARE PASSIONATE ABOUT APPLYING AND DEVELOPING NOW TECHNOLOGIES AND ABOUT TRANSLATING DISCOVERIES FROM OUR LAB INTO REALWORLD APPLICATIONS. THE DUDLEY LAB EXPERIMENTS IN YEAST BECAUSE YEAST CELLS FUNCTION IN MUCH THE SAME WAY AS HUMAN CELLS. HOWEVER, WITH YEAST, WE CAN PERFORM EXPERIMENTS MUCH FASTER, AND ON A GRANDER SCALE, THAN SCIENTISTS CAN WITH HUMAN CELLS.
  3. $1.2 million spent. THE CARVALHO LAB STUDIES HOW, WHEN, AND WHY HUMAN GENOMIC VARIANTS OCCUR AND CONTRIBUTE TO THE DEVELOPMENT OF DISEASE AND DISABILITY.
  4. $1.1 million spent. THE HAGOPIAN LAB RESEARCHES WAYS TO PREDICT AND PREVENT THE DEVELOPMENT OF TYPE 1 DIABETES, A DISEASE AFFECTING OVER ONE MILLION AMERICAN CHILDREN AND ADULTS. NOT EVERYONE WITH GENETIC RISK FOR TYPE 1 DIABETES DEVELOPS THE DISEASE. WHY NOT? SCIENTISTS IN THE HAGOPIAN LAB BELIEVE ANSWERS LIE IN THE ENVIRONMENT. THEY ARE ONE OF 6 LABS PARTICIPATING IN AN INTERNATIONAL STUDY FOLLOWING 8,000 CHILDREN WITH HIGH GENETIC RISK FOR TYPE 1 DIABETES. THE HAGOPIAN LAB ALSO DEVELOPS POPULATION BASED NEWBORN SCREENING METHODS TO PREDICT WHO IS AT RISK. THE ULTIMATE GOAL IS TO PREVENT THE DISEASE ENTIRELY.

Source: Form 990 for the year ending September 30, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Legitimacy checks

  1. Is it registered with the IRS? Passed.

    Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.

  2. Has the IRS revoked its tax-exempt status? Passed.

    Not on the IRS automatic revocation list.

    Source: Automatic revocation of exemption list, Internal Revenue Service, file dated September 30, 2026.

  3. Are donations tax-deductible? Passed.

    On the IRS list of organizations eligible to receive tax-deductible contributions.

    Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated September 10, 2026.

  4. Is it keeping up with its IRS filings? Passed.

    Most recent return on file covers the year ending September 2025.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.

  5. How long has it been tax-exempt? Passed.

    Recognized by the IRS since June 1958.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.

  6. Is it in good standing with state regulators? Passed.

    Not on California's list of charities barred from soliciting. Other states are not yet checked.

    Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated October 7, 2026.

Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.