Open Molecular Software Foundation
Public records show a registered, tax-exempt organization in good standing.
What it says it does
OMSF's mission is to advance the molecular sciences through the development of high-quality, open-source tools for molecular modeling and facilitating collaboration between industry and academia.
- Income
- $5.4 million
- Spending
- $5.3 million
- Spent on programs
- 94%
- Reserves
- 1.2 months of spending
- Largest source of income
- donations and private grants, 52%
- Employees
- 17
- Volunteers
- 46
- Highest pay
- $208,101, ml scientist
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Financial health
Fair: 60 out of 100. Higher than 28% of charities in its peer group (science, $1m to $10m).
Reserves
10 of 35Spendable reserves would cover 1.2 months of spending.
Debt
5 of 20It owes 67% of what it owns.
Living within its means
15 of 15Income exceeded spending by 3% of income.
Income trend
15 of 15Income rose 81% on the year before.
Spending floor
15 of 1594% of spending went to programs and raising each dollar of donations cost 0 cents.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Governance
Good: 77 out of 100. Higher than 30% of charities in its peer group (science, $1m to $10m).
Independent board
25 of 254 of 5 voting board members are independent.
Conflict of interest policy
15 of 15Has a written conflict of interest policy.
Whistleblower policy
0 of 8Reports no written whistleblower policy.
Record keeping policy
7 of 7Has a written policy on keeping and destroying records.
Board minutes
5 of 5Keeps minutes of board meetings.
Board sees the tax return
10 of 10Gave the board a copy of this return before filing it.
Pay set independently
5 of 5Sets its chief executive's pay through independent review and comparison.
Independent check of accounts
0 of 15Its accounts were not audited or reviewed by an independent accountant.
No reported misuse
10 of 10Reports no diversion of assets, excess benefits or loans to insiders.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Impact evidence
Describes programs. Its tax return describes what it does but we have found no measurable results in it.
Programs described in its return (1)
- $5.0 million spent. OMSF welcomed three new projects in 2024 OpenADMET, Alchemistry and Virtual Winter School of Computational Chemistry (VWSCC). Alchemistry and VWSCC are focused on community building efforts in the field of (bio)molecular modeling, more specifically, through organizing events for education, training and networking purposes. OpenADMET is the project with the mission to build open predictive models of safety and toxicity for small molecules to improve humanitys ability to more reliably, cheaply, and effectively treat disease, launched jointly with UCSF and Octant Bio. The OpenADMET project is funded by an ARPA-H grant (the primary awardee is UCSF). The number of staff members and core contributors continued to grow, and we had 27 staff members in 2024. OMSF successfully organized its second annual symposium in Leiden (Netherlands) and successfully gathered more than 100 attendees which included our staff members, industry partners and other members of the molecular modeling community. The list of our hosted projects, their missions and activities is provided below together with our program services and community-oriented efforts. Hosted ProjectsOpenADMETOpenADMET is an open effort to build predictive models of ADMET properties and understand the mechanisms by which they arise. This means systematically characterizing the proteins and mechanisms that give rise to these properties (protein structures and scaled functional and genetic assays), understanding how small molecules interact with these mechanisms (through high-throughput nanoscale chemistry to explore/exploit chemical space), and integrative computational models (AI/ML ligand/structural, mechanistic, and physiological modeling). OMSF is focused on AI/ML ligand and structural modeling, while UCSF and Octant Bios primary role is generation of high-quality datasets. The project was launched on Oct 1, 2024, and this effort is funded by an ARPA-H grant and Gates Foundation. More information about the project and its activities can be found on their website:https://openadmet.org/. OpenFold ConsortiumOpenFold is a non-profit AI research and development consortium developing free and open-source software tools for biology and drug discovery. OpenFolds mission is to bring the most powerful software ever created AI systems with the ability to engineer the molecules of life to everyone. These tools can be used by academics, biotech and pharmaceutical companies, or students learning to create the medicines of tomorrow, to accelerate basic biological research, and bring new cures to market that would be impossible to discover without AI. This project aims to:Collaboratively develop a permissively licensed model competitive with the performance of state-of-the-art models. Provide the entire training & inference stack and training datasets under the same permissive license Optimize the performance of this model for use on state-of-the-art and widely available GPUs. In 2024, the OpenFold Consortium started working on reproducing the AlphaFold3 model and releasing the resulting code, weights and data under permissive licenses. The consortium has grown from 10 to 14 industry members between 2023 and 2024. The list of current OpenFold members, links to software repositories and latest news about their activities can be found on their website (https://openfold.io). Open Force Field ConsortiumThe Open Force Field Consortium (OpenFF) is a network of academic and industry researchers working together to advance science and infrastructure required for building the next generation of small molecule and biomolecular force fields. The shared goal of these researchers is to develop automated and systematic data-driven techniques to parameterize and assess new generations of more accurate force fields. Software and data are released under open licensing agreements to enable rapid application, validation, extension and any kind of modification by our users and contributors. In addition, the Initiative aims to build and support a strong community of users and contributors from industry and academia. The OpenFF Sage 2.2 release delivered targeted improvements to critical pharmaceutical chemistries. Independent validation demonstrated that OpenFF outperforms leading commercial packages on challenging BACE1 scaffold-hopping transformations, confirming the force field's competitive accuracy. A major new feature is the preview release of a graph neural network model for ultra-fast, conformation-independent charge assignment that operates 10-100x faster than traditional methods with improved accuracy and elimination of conformer-dependent errors. This method scales seamlessly to large biomolecules including proteins and polymers, enabling self-consistent parameterization across all molecular types including non-natural amino acids. Infrastructure development released the production-ready Alchemiscale platform completing over 100,000 binding free energy calculations on free academic compute resources and being adopted extensively by OpenFF, OpenFE, and the ASAP Antiviral Drug Discovery Consortium for routine force field testing. The YAMMBS automated benchmarking system enabled testing of 75+ different force field fits over the past year while identifying and correcting systematic errors through continuous validation of molecular geometries and energetics. Significant progress was made toward the self-consistent protein + small molecule force field ("Rosemary"), with the team generating requisite peptide quantum chemical data and achieving performance matching AMBER ff14SB on specific benchmarks; a recent breakthrough in fitting strategy using trajectory reweighting has dramatically accelerated progress, putting the release on track for the upcoming project year to enable truly accurate protein-ligand binding with fully consistent parameterization. Additional technical developments included completion of virtual site infrastructure, advancement of automated chemical perc
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Legitimacy checks
Is it registered with the IRS? Passed.
Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.
Has the IRS revoked its tax-exempt status? Passed.
Not on the IRS automatic revocation list.
Source: Automatic revocation of exemption list, Internal Revenue Service, file dated September 30, 2026.
Are donations tax-deductible? Passed.
On the IRS list of organizations eligible to receive tax-deductible contributions.
Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated September 10, 2026.
Is it keeping up with its IRS filings? Passed.
Most recent return on file covers the year ending December 2024.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.
How long has it been tax-exempt? Passed.
Recognized by the IRS since June 2022.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.
Is it in good standing with state regulators? Passed.
Not on California's list of charities barred from soliciting. Other states are not yet checked.
Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated October 7, 2026.
Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.