Skip to the page content
Your donations
Passes our checks

Sophies Neighborhood

EIN 84-5178467 · Boulder, CO

Public records show a registered, tax-exempt organization in good standing.

LegitimacyPassesRegistration and standingFinancial healthGood85 out of 100GovernanceWeak19 out of 100Impact evidenceDescribes programsHow well its results are evidenced

What it says it does

SOPHIE'S NEIGHBORHOOD IS A NONPROFIT DEDICATED TO FUNDRAISING FOR RESEARCH INTO THE DEVELOPMENT OF AN EFFECTIVE TREATMENT OR CURE FOR AN ULTRA RARE GENETIC DISORDER: MULTICENTRIC CARPOTARSAL OSTEOLYSIS (MCTO)

Income
$133,087
Spending
$109,440
Spent on programs
92%
Reserves
111.9 months of spending
Largest source of income
donations and private grants, 100%
Employees
0
Volunteers
5

Source: Form 990 for the year ending April 30, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Financial health

Good: 85 out of 100. Higher than 64% of charities in its peer group (health care, under $250k).

  • Reserves

    35 of 35

    Spendable reserves would cover 111.9 months of spending.

  • Debt

    20 of 20

    It owes 0% of what it owns.

  • Living within its means

    15 of 15

    Income exceeded spending by 18% of income.

  • Income trend

    0 of 15

    Income fell 42% on the year before.

  • Spending floor

    15 of 15

    92% of spending went to programs and raising each dollar of donations cost 1 cents.

Source: Form 990 for the year ending April 30, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Governance

Weak: 19 out of 100. Higher than 2% of charities in its peer group (health care, under $250k).

  • Independent board

    0 of 25

    0 of 2 voting board members are independent.

  • Conflict of interest policy

    0 of 15

    Reports no written conflict of interest policy.

  • Whistleblower policy

    0 of 8

    Reports no written whistleblower policy.

  • Record keeping policy

    0 of 7

    Reports no written policy on keeping and destroying records.

  • Board minutes

    5 of 5

    Keeps minutes of board meetings.

  • Board sees the tax return

    0 of 10

    Did not give the board a copy of this return before filing it.

  • No reported misuse

    10 of 10

    Reports no diversion of assets, excess benefits or loans to insiders.

Source: Form 990 for the year ending April 30, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Impact evidence

Describes programs. Its tax return describes what it does but we have found no measurable results in it.

Programs described in its return (1)
  1. $101,120 spent. DURING THE FISCAL YEAR ENDING APRIL 2025, SOPHIE'S NEIGHBORHOOD FUNDED MAJOR RESEARCH INITIATIVES TO ADVANCE UNDERSTANDING AND TREATMENT OF MULTICENTRIC CARPO-TARSAL OSTEOLYSIS (MCTO) AN ULTRA RARE GENETIC BONE AND KIDNEY DISORDER. 1.ADVANCING MCTO DISEASE MECHANISMS THROUGH INNOVATIVE MOUSE MODELS SOPHIE'S NEIGHBORHOOD SUPPORTED RESEARCH AT HARVARD SCHOOL OF DENTAL MEDICINE INVESTIGATING BONE REMODELING ACTIVITY AND CELLULAR CHANGES MAFB MOUSE MODELS OF MCTO. THIS WORK INCLUDES TRANSCRIPTOMIC ANALYSES OF CELLS AND TISSUES WITHIN THE SKELETAL MICROENVIRONMENT TO UNCOVER MOLECULAR MECHANISMS DRIVING DISEASE PROGRESSION. 2.EXPANDING STEM CELL-BASED AND DEVELOPMENTAL MODELS OF MCTO IN COLLABORATION WITH BOSTON CHILDREN'S HOSPITAL, SOPHIE'S NEIGHBORHOOD CONTINUED TO FUND STUDIES ON MAFB AND DEVELOPMENTAL CHONDROGENESIS. THESE EFFORTS ADVANCE STEM CELL-BASED MODELS OF MCTO AND IDENTIFY KEY TRANSCRIPTIONAL NETWORKS INVOLVED IN BONE AND CARTILAGE DEVELOPMENT. 3.ESTABLISHING CRITICAL RESEARCH INFRASTRUCTURE FOR RARE DISEASE DISCOVERY SOPHIE'S NEIGHBORHOOD SUPPORTED THE CREATION AND ONGOING MAINTENANCE OF MCTO MOUSE LINES WITH SPECIFIC MAFB MUTATIONS AT THE JACKSON LABORATORY. THESE SPECIALIZED MODELS ENABLE RESEARCHERS TO TEST HYPOTHESES RELATED TO MAFB PROTEIN ACCUMULATION AND DISEASE PATHOLOGY, STRENGTHENING THE FOUNDATION FOR FUTURE THERAPEUTIC RESEARCH. 4.INITIATE ANTISENSE OLIGONUCLEOTIDE (ASO) DEVELOPMENT AND SCREENING TO EVALUATE THERAPEUTIC EFFICACY IN CELLULAR AND MOUSE MODELS, WITH THE GOAL OF REVERSING BONE AND KIDNEY PHENOTYPES ASSOCIATED WITH MCTO. DURING THE FISCAL YEAR ENDING APRIL 2025, SOPHIE'S NEIGHBORHOOD FUNDED MAJOR RESEARCH INITIATIVES TO ADVANCE UNDERSTANDING AND TREATMENT OF MULTICENTRIC CARPO-TARSAL OSTEOLYSIS (MCTO) AN ULTRA RARE GENETIC BONE AND KIDNEY DISORDER. 1.ADVANCING MCTO DISEASE MECHANISMS THROUGH INNOVATIVE MOUSE MODELS SOPHIE'S NEIGHBORHOOD SUPPORTED RESEARCH AT HARVARD SCHOOL OF DENTAL MEDICINE INVESTIGATING BONE REMODELING ACTIVITY AND CELLULAR CHANGES MAFB MOUSE MODELS OF MCTO. THIS WORK INCLUDES TRANSCRIPTOMIC ANALYSES OF CELLS AND TISSUES WITHIN THE SKELETAL MICROENVIRONMENT TO UNCOVER MOLECULAR MECHANISMS DRIVING DISEASE PROGRESSION. 2.EXPANDING STEM CELL-BASED AND DEVELOPMENTAL MODELS OF MCTO IN COLLABORATION WITH BOSTON CHILDREN'S HOSPITAL, SOPHIE'S NEIGHBORHOOD CONTINUED TO FUND STUDIES ON MAFB AND DEVELOPMENTAL CHONDROGENESIS. THESE EFFORTS ADVANCE STEM CELL-BASED MODELS OF MCTO AND IDENTIFY KEY TRANSCRIPTIONAL NETWORKS INVOLVED IN BONE AND CARTILAGE DEVELOPMENT. 3.ESTABLISHING CRITICAL RESEARCH INFRASTRUCTURE FOR RARE DISEASE DISCOVERY SOPHIE'S NEIGHBORHOOD SUPPORTED THE CREATION AND ONGOING MAINTENANCE OF MCTO MOUSE LINES WITH SPECIFIC MAFB MUTATIONS AT THE JACKSON LABORATORY. THESE SPECIALIZED MODELS ENABLE RESEARCHERS TO TEST HYPOTHESES RELATED TO MAFB PROTEIN ACCUMULATION AND DISEASE PATHOLOGY, STRENGTHENING THE FOUNDATION FOR FUTURE THERAPEUTIC RESEARCH. 4.INITIATE ANTISENSE OLIGONUCLEOTIDE (ASO) DEVELOPMENT AND SCREENING TO EVALUATE THERAPEUTIC EFFICACY IN CELLULAR AND MOUSE MODELS, WITH THE GOAL OF REVERSING BONE AND KIDNEY PHENOTYPES ASSOCIATED WITH MCTO.

Source: Form 990 for the year ending April 30, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Legitimacy checks

  1. Is it registered with the IRS? Passed.

    Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.

  2. Has the IRS revoked its tax-exempt status? Passed.

    Not on the IRS automatic revocation list.

    Source: Automatic revocation of exemption list, Internal Revenue Service, file dated November 6, 2026.

  3. Are donations tax-deductible? Passed.

    On the IRS list of organizations eligible to receive tax-deductible contributions.

    Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated October 13, 2026.

  4. Is it keeping up with its IRS filings? Passed.

    Most recent return on file covers the year ending April 2025.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.

  5. How long has it been tax-exempt? Passed.

    Recognized by the IRS since April 2020.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.

  6. Is it in good standing with state regulators? Passed.

    Not on California's list of charities barred from soliciting. Other states are not yet checked.

    Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated November 4, 2026.

Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.