Skip to the page content
Your donations
Passes our checks

Chan Zuckerberg Biohub Inc

EIN 81-1669175 · Redwood City, CA

Public records show a registered, tax-exempt organization in good standing.

LegitimacyPassesRegistration and standingFinancial healthFair63 out of 100GovernanceStrong100 out of 100Impact evidenceDescribes programsHow well its results are evidenced

What it says it does

ACCELERATING SCIENCE THROUGH ITS MISSION TO CURE, PREVENT OR MANAGE ALL DISEASES BY THE END OF THE 21ST CENTURY.

Income
$99.6 million
Spending
$142.4 million
Spent on programs
85%
Reserves
11.2 months of spending
Largest source of income
donations and private grants, 80%
Employees
290
Volunteers
8
Highest pay
$965,995, director, president czb sf (key emp)

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Financial health

Fair: 63 out of 100. Higher than 36% of charities in its peer group (medical research, $10m to $100m).

  • Reserves

    28 of 35

    Spendable reserves would cover 11.2 months of spending.

  • Debt

    20 of 20

    It owes 6% of what it owns.

  • Living within its means

    0 of 15

    Spending exceeded income by 43% of income.

  • Income trend

    0 of 15

    Income fell 92% on the year before.

  • Spending floor

    15 of 15

    85% of spending went to programs and raising each dollar of donations cost 0 cents.

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Governance

Strong: 100 out of 100. Higher than 45% of charities in its peer group (medical research, $10m to $100m).

  • Independent board

    25 of 25

    6 of 10 voting board members are independent.

  • Conflict of interest policy

    15 of 15

    Has a written conflict of interest policy.

  • Whistleblower policy

    8 of 8

    Has a written whistleblower policy.

  • Record keeping policy

    7 of 7

    Has a written policy on keeping and destroying records.

  • Board minutes

    5 of 5

    Keeps minutes of board meetings.

  • Board sees the tax return

    10 of 10

    Gave the board a copy of this return before filing it.

  • Pay set independently

    5 of 5

    Sets its chief executive's pay through independent review and comparison.

  • Independent check of accounts

    15 of 15

    Its accounts were audited by an independent accountant.

  • No reported misuse

    10 of 10

    Reports no diversion of assets, excess benefits or loans to insiders.

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Impact evidence

Describes programs. Its tax return describes what it does but we have found no measurable results in it.

Programs described in its return (1)
  1. $121.5 million spent. IN 2024, THE FOUR RESEARCH INSTITUTES OF CHAN ZUCKERBERG BIOHUB INC ("BIOHUB") MADE SIGNIFICANT ADVANCES IN THE ORGANIZATION'S OVERALL MISSION TO CURE, PREVENT OR MANAGE DISEASE.IN JUNE, RESEARCHERS AT THE CHAN ZUCKERBERG INSTITUTE FOR ADVANCED BIOLOGICAL IMAGING ANNOUNCED THAT THEY HAD SOLVED A MAJOR BOTTLENECK IN THE USE OF THE IMAGING TECHNIQUE KNOWN AS CRYOGENIC ELECTRON TOMOGRAPHY, OR CRYOET. THIS METHOD IS CAPABLE OF CAPTURING DETAILED STRUCTURAL IMAGES OF CELLS AND PROTEINS, BUT THE RESULTING 3D DATASETS, KNOWN AS TOMOGRAMS, MUST BE MANUALLY ANNOTATED, A PAINSTAKING PROCESS THAT CAN TAKE MONTHS, SLOWING THE PACE OF SCIENTIFIC DISCOVERY. BY APPLYING NEW MACHINE LEARNING TOOLS, THE IMAGING INSTITUTE RESEARCHERS AUTOMATICALLY ANNOTATED 13,000 TOMOGRAMS IN JUST THREE-AND-A-HALF DAYS. IN ADDITION, THE INSTITUTE LAUNCHED THE CRYOET DATA PORTAL, AN OPEN ACCESS DATA REPOSITORY THAT CONTAINS ABOUT 16,000 ANNOTATED CRYOET DATASETS IN STANDARDIZED FORMATS. BOTH ACHIEVEMENTS WILL BENEFIT BIOIMAGING SCIENTISTS WORLDWIDE BY ACCELERATING UNDERSTANDING OF THE PROTEINS THAT MAKE UP OUR CELLS.IN A SCIENTIFIC MILESTONE, THE SAN FRANCISCO BIOHUB RESEARCHERS RELEASED "ZEBRAHUB," AN ATLAS OF EARLY ZEBRAFISH DEVELOPMENT. PUBLISHED IN THE JOURNAL CELL IN NOVEMBER, ZEBRAHUB COMBINES STATE-OF-THE-ART 3D MICROSCOPY WITH COMPREHENSIVE GENE-EXPRESSION DATA FOR THE INDIVIDUAL CELLS THAT MAKE UP ZEBRAFISH EMBRYOS. THE MICROSCOPES, GENE-SEQUENCING TECHNIQUES, AND IMAGE ANALYSIS TOOLS USED TO CREATE ZEBRAHUB WERE DESIGNED AND BUILT AT THE BIOHUB. ABOUT 70% OF HUMAN GENES, INCLUDING THOSE INVOLVED IN DISEASES, HAVE COUNTERPARTS IN ZEBRAFISH, SO ZEBRAHUB WILL ACCELERATE DISEASE RESEARCH ACROSS CANCER, HEART DISEASE, AND NEUROLOGICAL DISORDERS PROVIDING FREELY ACCESSIBLE DATA THAT WILL HELP BIOMEDICAL RESEARCHERS WORLDWIDE IDENTIFY NEW TREATMENTS.OCTOBER SAW THE OFFICIAL LAUNCH OF THE NEW YORK BIOHUB, DEVOTED TO CHARACTERIZING AND ENGINEERING THE BEHAVIOR OF OUR IMMUNE CELLS. THESE ENGINEERED CELLS CAN BE ADAPTED TO DETECT SIGNALS THAT PREDICT SEVERAL DISEASES, FROM CANCERS TO ALZHEIMER'S AND PARKINSON'S, AT THEIR EARLIEST STAGES, WHEN THEY ARE EASIER TO TREAT OR PREVENT, AND LONG BEFORE THEY CAN BE DETECTED BY CONVENTIONAL DIAGNOSTIC METHODS. THE NEW YORK BIOHUB ALSO BEGAN CONSTRUCTION OF PERMANENT, STATE-OF-THE-ART LAB SPACE ON COLUMBIA UNIVERSITY'S MANHATTANVILLE CAMPUS, MADE NEW HIRES, AND FUNDED ITS FIRST COHORT OF INVESTIGATORS FROM ITS PARTNER INSTITUTIONS: COLUMBIA UNIVERSITY, THE ROCKEFELLER UNIVERSITY, AND YALE UNIVERSITY.THE TEAM AT CHICAGO BIOHUB TACKLED A LONGSTANDING PROBLEM IN BIOENGINEERING BY BUILDING A FIRST-OF-ITS-KIND IMPLANTABLE SENSOR THAT CAN MONITOR LEVELS OF THE PROTEINS INVOLVED IN INFLAMMATION IN REAL TIME. SENSORS THAT MONITOR GLUCOSE, A SMALL MOLECULE, HAVE REVOLUTIONIZED DIABETES CARE, BUT SCIENTISTS HAVE STRUGGLED TO OBTAIN THE RELIABLE, CONTINUOUS MEASUREMENTS OF PROTEINS ACHIEVED BY THE NEW SENSOR, AS REPORTED IN THE JOURNAL SCIENCE IN DECEMBER. IT HAS BEEN ESTIMATED THAT 50% OF ALL DEATHS ARE RELATED TO INFLAMMATORY CONDITIONS, AND THE NOVEL SENSOR PLACES AN IMPORTANT NEW TOOL IN THE HANDS OF RESEARCHERS TO BETTER UNDERSTAND AND POTENTIALLY PREVENT A RANGE OF DISEASES, FROM NEURODEGENERATION TO CANCER TO HEART DISEASE.

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Legitimacy checks

  1. Is it registered with the IRS? Passed.

    Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.

  2. Has the IRS revoked its tax-exempt status? Passed.

    Not on the IRS automatic revocation list.

    Source: Automatic revocation of exemption list, Internal Revenue Service, file dated October 13, 2026.

  3. Are donations tax-deductible? Passed.

    On the IRS list of organizations eligible to receive tax-deductible contributions.

    Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated October 13, 2026.

  4. Is it keeping up with its IRS filings? Passed.

    Most recent return on file covers the year ending December 2024.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.

  5. How long has it been tax-exempt? Passed.

    Recognized by the IRS since September 2016.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.

  6. Is it in good standing with state regulators? Passed.

    Not on California's list of charities barred from soliciting. Other states are not yet checked.

    Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated October 21, 2026.

Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.