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N of One

EIN 46-4870147 · Dallas, TX

Public records show a registered, tax-exempt organization in good standing.

LegitimacyPassesRegistration and standingFinancial healthNot ratedToo small or too little detailGovernanceStrong91 out of 100Impact evidenceDescribes programsHow well its results are evidenced

What it says it does

N of One aims to create breakthroughs in autism by focusing on emerging areas such as the microbiome, immune system, and mitochondrial cell metabolism. We take a venture capital appproach by supporting both innovative academic researchers as well as start-ups pursuing novel, transformative approaches.

Income
$95,021
Spending
$25,283
Spent on programs
81%
Reserves
Over 10 years of spending
Largest source of income
donations and private grants, 71%
Employees
0
Volunteers
4

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Financial health

We do not score finances when yearly spending is very small or the return has too little detail. The ratios stop meaning much at that size.

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Governance

Strong: 91 out of 100. Higher than 84% of charities in its peer group (medical research, under $250k).

  • Independent board

    18 of 25

    4 of 4 voting board members are independent.

  • Conflict of interest policy

    15 of 15

    Has a written conflict of interest policy.

  • Whistleblower policy

    8 of 8

    Has a written whistleblower policy.

  • Record keeping policy

    7 of 7

    Has a written policy on keeping and destroying records.

  • Board minutes

    5 of 5

    Keeps minutes of board meetings.

  • Board sees the tax return

    10 of 10

    Gave the board a copy of this return before filing it.

  • No reported misuse

    10 of 10

    Reports no diversion of assets, excess benefits or loans to insiders.

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Impact evidence

Describes programs. Its tax return describes what it does but we have found no measurable results in it.

Programs described in its return (2)
  1. $20,025 spent. N of One directly funds research and actively works with researchers at top institutions to create breakthroughs for autism by focusing on historically underfunded areas such as the immune system, the microbiome, and cell metabolism or combinations thereof. N of One has projects underway in each of these three core areas. N of One is continuously identifying new, high-potential research projects that can lead to novel treatment, diagnostic, and prevention strategies in our lifetime. Additionally N of One seeks to invest in and support commercialization of promising breakthroughs to help them to market faster.
  2. $543 spent. N of One believes that an integral part of its mission is to communicate the latest promising scientific developments to the public. N of One disseminates information via its website, social media, and its periodic newsletter to subscribers including its monthly Research Round Up highlighting and summarizing recent important research for its subscribers. N of One works with the media and press to help support the publication of the latest scientific breakthroughs to as wide an audience as possible.

Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate

Legitimacy checks

  1. Is it registered with the IRS? Passed.

    Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.

  2. Has the IRS revoked its tax-exempt status? Passed.

    Not on the IRS automatic revocation list.

    Source: Automatic revocation of exemption list, Internal Revenue Service, file dated September 30, 2026.

  3. Are donations tax-deductible? Passed.

    On the IRS list of organizations eligible to receive tax-deductible contributions.

    Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated September 10, 2026.

  4. Is it keeping up with its IRS filings? Passed.

    Most recent return on file covers the year ending December 2024.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.

  5. How long has it been tax-exempt? Passed.

    Recognized by the IRS since June 2016.

    Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.

  6. Is it in good standing with state regulators? Passed.

    Not on California's list of charities barred from soliciting. Other states are not yet checked.

    Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated October 7, 2026.

Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.