Hennepin Healthcare Research Institute
Public records show a registered, tax-exempt organization in good standing.
What it says it does
IMPROVE PATIENT CARE AND THE HEALTH OF OUR COMMUNITY THROUGH RESEARCH AND EDUCATION.
- Income
- $54.7 million
- Spending
- $53.5 million
- Spent on programs
- 92%
- Reserves
- 7.5 months of spending
- Largest source of income
- government grants, 59%
- Employees
- 266
- Volunteers
- 202
- Highest pay
- $660,695, director/physician (until 6/24)
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Financial health
Good: 88 out of 100. Higher than 72% of charities in its peer group (medical research, $10m to $100m).
Reserves
28 of 35Spendable reserves would cover 7.5 months of spending.
Debt
20 of 20It owes 14% of what it owns.
Living within its means
15 of 15Income exceeded spending by 2% of income.
Income trend
10 of 15Income fell 4% on the year before.
Spending floor
15 of 1592% of spending went to programs and raising each dollar of donations cost 0 cents.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Governance
Good: 80 out of 100. Higher than 13% of charities in its peer group (medical research, $10m to $100m).
Independent board
5 of 257 of 14 voting board members are independent.
Conflict of interest policy
15 of 15Has a written conflict of interest policy.
Whistleblower policy
8 of 8Has a written whistleblower policy.
Record keeping policy
7 of 7Has a written policy on keeping and destroying records.
Board minutes
5 of 5Keeps minutes of board meetings.
Board sees the tax return
10 of 10Gave the board a copy of this return before filing it.
Pay set independently
5 of 5Sets its chief executive's pay through independent review and comparison.
Independent check of accounts
15 of 15Its accounts were audited by an independent accountant.
No reported misuse
10 of 10Reports no diversion of assets, excess benefits or loans to insiders.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Impact evidence
Describes programs. Its tax return describes what it does but we have found no measurable results in it.
Programs described in its return (2)
- $44.2 million spent. CLINICAL RESEARCH AND EDUCATIONAL ACTIVITIES:HENNEPIN HEALTHCARE RESEARCH INSTITUTE (HHRI) INVESTIGATORS ARE PRACTICING PHYSICIANS, SCIENTISTS AND OTHER MEDICAL PROFESSIONALS USING THEIR EXPERTISE TO ADVANCE MEDICAL KNOWLEDGE AND IMPROVE THE CARE PATIENTS RECEIVE. HHRI'S RESEARCH SUBJECTS ARE DIVERSE WITH A FOCUS ON ACUTE CARE/TRAUMA, ADDICTION, HEALTH SERVICES, AND INFECTIOUS DISEASES. PARTICIPANTS IN HHRI CLINICAL RESEARCH STUDIES (INCLUDING TRAUMATIC BRAIN INJURY, SUBSTANCE USE DISORDERS, DEMENTIA, CHRONIC DISEASES, AND HIV/AIDS) HAVE ACCESS TO SOME OF THE LATEST MEDICAL TREATMENTS AVAILABLE TODAY. IN ADDITION TO PURSUING INNOVATIVE NEW THERAPIES, OUR INVESTIGATORS ARE TRAINING THE NEXT GENERATION OF SCIENTISTS AND MEDICAL PROFESSIONALS, INSPIRING THEM TO CARRY OUT HHRI'S MISSION OF IMPROVING PATIENT CARE AND THE HEALTH OF OUR COMMUNITY THROUGH RESEARCH AND EDUCATION. OUR INVESTIGATORS ALSO PUBLISH REGULARLY IN PEER-REVIEWED JOURNALSSEE SCHEDULE O - GENERAL STATEMENT. AT THE HENNEPIN HEALTHCARE RESEARCH INSTITUTE (HHRI), OUR INVESTIGATORS HAVE BEEN TRANSLATING SCIENTIFIC KNOWLEDGE INTO DISCOVERIES THAT MAKE A DIFFERENCE SINCE 1952. WE ACTIVELY INVESTIGATE THE CAUSES OF AND POTENTIAL TREATMENTS FOR DISEASES, GUIDED BY OUR GOALS OF ADVANCING MEDICAL KNOWLEDGE AND OUR MISSION OF IMPROVING PATIENT CARE AND THE HEALTH OF OUR COMMUNITY THROUGH RESEARCH AND EDUCATION. HHRI IS PART OF HENNEPIN HEALTHCARE, AN INTEGRATED SYSTEM OF CARE THAT INCLUDES HCMC, A NATIONALLY RECOGNIZED LEVEL 1 ADULT AND PEDIATRIC TRAUMA CENTER AND AN ESSENTIAL TEACHING AND SAFETY NET HOSPITAL. HHRI SUPPORTS AND OVERSEES THE MEDICAL RESEARCH CARRIED OUT AT HCMC. THE WIDE-RANGE OF MEDICAL SPECIALTIES HCMC OFFERS AND A DIVERSE PATIENT POPULATION ENABLE HHRI INVESTIGATORS TO ESTABLISH CROSS-FUNCTIONAL COLLABORATIONS TO EXPLORE NEW AND INNOVATIVE WAYS TO UNDERSTAND AND TREAT DISEASE. HHRI IS ONE OF THE LARGEST NONPROFIT MEDICAL RESEARCH ORGANIZATIONS IN MINNESOTA. IT SUPPORTS THE WORK OF MORE THAN 200 RESEARCH STAFF AND INVESTIGATORS (MDS, MD/PHDS, PHDS AND PHARMDS). IN 2024, HHRI RECEIVED 151 NEW OR RENEWING SPONSORED AWARDS WITH OVER 75% OF FUNDING COMING FROM STATE AND FEDERAL GOVERNMENTS. FUNDING ALSO CAME FROM PRIVATE FOUNDATIONS, INDUSTRY PARTNERS, AND CORPORATE AND INDIVIDUAL DONATIONS. HHRI CONSISTENTLY RANKS NATIONALLY IN THE TOP 10% OF INSTITUTIONS RECEIVING FUNDING FROM THE NATIONAL INSTITUTES OF HEALTH (NIH). HHRI RESEARCHERS ARE EXPERTS IN THEIR FIELDS TACKLING OUR BIGGEST HEALTHCARE CHALLENGES, INCLUDING HIV/AIDS, SUBSTANCE USE DISORDERS, LIFE-THREATENING AND TIME-SENSITIVE CONDITIONS, CHRONIC DISEASES, AND ACCESS TO CARE. THEY CONDUCT BASIC, TRANSLATIONAL, CLINICAL, AND EPIDEMIOLOGIC RESEARCH WITH A FOCUS ON ACUTE CARE/TRAUMA, ADDICTION, HEALTH SERVICES, AND INFECTIOUS DISEASES. IN 2024, HHRI RESEARCHERS MADE SIGNIFICANT CONTRIBUTIONS TO THE STUDY AND PRACTICE OF MEDICINE IN THE FOLLOWING SPECIALTIES: ACUTE CARE/TRAUMA - CARDIAC BIOMARKERS - CARDIOPULMONARY RESUSCITATION - EMERGENCY MEDICINE - FROSTBITE AND BURN - INFECTIOUS DISEASES / SEPSIS - NEUROSURGERY - ORTHOPAEDICS - PULMONARY AND CRITICAL CARE MEDICINE - TRAUMA AND CRITICAL CARE - TRAUMA AND SURGICAL CRITICAL CARE - TRAUMATIC BRAIN INJURY (TBI) - TBI AND CORTICAL SPREADING DEPOLARIZATION (CSD) ADDICTION - ADDICTION MEDICINE - OPIOID TREATMENT RESEARCH - REDUCING THE IMPACT OF TOBACCO-RELATED DISEASES - TOBACCO CESSATION / BEHAVIOR HEALTH - TOBACCO TREATMENT RESEARCH HEALTH SERVICES - BRAIN HEALTH AND CEREBROVASCULAR CARE - CLINICAL OUTCOMES RESEARCH - CANCER - CHILDREN'S ISSUES - CHRONIC DISEASES - DEMENTIA AND AGING - DIABETES AND OBESITY - HEALTH, HOMELESSNESS, AND CRIMINAL JUSTICE - KIDNEY DISEASE - NEPHROLOGY, TRANSPLANTATION AND HEALTH DISPARITIES AND PHARMACOGENOMICS - NEUROLOGY, ALS, AND NEUROPALLIATIVE CARE - ORGAN TRANSPLANTATION INFECTIOUS DISEASES - COVID-19 - HIV / AIDS - HEPATITIS B AND C - IMMUNE THERAPY AND IMMUNOLOGY - MALARIA IMMUNOLOGY - SEXUALLY TRANSMITTED INFECTIONS, HIV PREVENTION THE MAJORITY OF OUR RESEARCH PROJECTS ARE TRANSLATIONAL IN NATURE. TRANSLATIONAL RESEARCH SEEKS TO TAKE DISCOVERIES MADE IN A LABORATORY SETTING AND TRANSLATE THEM INTO THERAPIES PHYSICIANS CAN USE IN THEIR MEDICAL PRACTICES TO IMPROVE THE LIVES OF PATIENTS LOCALLY AND AROUND THE GLOBE. IN AN ENVIRONMENT THAT EMPHASIZES PATIENT CARE, RESEARCH AND TEACHING, HHRI IS AT THE FOREFRONT OF DISCOVERING SOLUTIONS TO SOME OF THE MOST COMPLEX MEDICAL PROBLEMS. THE WORK OF OUR INVESTIGATORS IS ADVANCING MEDICINE TO ENSURE A HEALTHIER TOMORROW FOR ALL MEMBERS OF OUR COMMUNITY. FOR MORE INFORMATION ABOUT HHRI VISIT OUR WEBSITE AT WWW.HHRINSTITUTE.ORG.
- $5.1 million spent. PRE-CLINICAL AND LABORATORY RESEARCH:IN THE HHRI LABS, WE STUDY THE CAUSES AND TREATMENTS OF DISEASE. OUR RESEARCH SUBJECTS ARE DIVERSE WITH A FOCUS ON ACUTE CARE/TRAUMA, ADDICTION, HEALTH SERVICES, AND INFECTIOUS DISEASES. AT HHRI, WE DEVELOP INNOVATIVE NEW TREATMENTS TO SOLVE SOME OF OUR COMMUNITY'S MOST-CHALLENGING HEALTH PROBLEMS. RESEARCHERS IN OUR LABS ARE MDS, MD/PHDS, PHDS, PHARMDS, AND OTHER MEDICAL AND SCIENCE PROFESSIONALS WORKING TO ADVANCE MEDICAL KNOWLEDGE AND IMPROVE THE CARE PATIENTS RECEIVE. OUR INVESTIGATORS ALSO PUBLISH REGULARLY IN PEER-REVIEWED JOURNALS SEE SCHEDULE O - GENERAL STATEMENT. AT THE HENNEPIN HEALTHCARE RESEARCH INSTITUTE (HHRI), OUR INVESTIGATORS HAVE BEEN TRANSLATING SCIENTIFIC KNOWLEDGE INTO DISCOVERIES THAT MAKE A DIFFERENCE SINCE 1952. WE ACTIVELY INVESTIGATE THE CAUSES OF AND POTENTIAL TREATMENTS FOR DISEASES, GUIDED BY OUR GOALS OF ADVANCING MEDICAL KNOWLEDGE AND OUR MISSION OF IMPROVING PATIENT CARE AND THE HEALTH OF OUR COMMUNITY THROUGH RESEARCH AND EDUCATION. HHRI IS PART OF HENNEPIN HEALTHCARE, AN INTEGRATED SYSTEM OF CARE THAT INCLUDES HCMC, A NATIONALLY RECOGNIZED LEVEL 1 ADULT AND PEDIATRIC TRAUMA CENTER AND AN ESSENTIAL TEACHING AND SAFETY NET HOSPITAL. HHRI SUPPORTS AND OVERSEES THE MEDICAL RESEARCH CARRIED OUT AT HCMC. THE WIDE-RANGE OF MEDICAL SPECIALTIES HCMC OFFERS AND A DIVERSE PATIENT POPULATION ENABLE HHRI INVESTIGATORS TO ESTABLISH CROSS-FUNCTIONAL COLLABORATIONS TO EXPLORE NEW AND INNOVATIVE WAYS TO UNDERSTAND AND TREAT DISEASE. HHRI IS ONE OF THE LARGEST NONPROFIT MEDICAL RESEARCH ORGANIZATIONS IN MINNESOTA. IT SUPPORTS THE WORK OF MORE THAN 200 RESEARCH STAFF AND INVESTIGATORS (MDS, MD/PHDS, PHDS AND PHARMDS). IN 2024, HHRI RECEIVED 151 NEW OR RENEWING SPONSORED AWARDS WITH OVER 75% OF FUNDING COMING FROM STATE AND FEDERAL GOVERNMENTS. FUNDING ALSO CAME FROM PRIVATE FOUNDATIONS, INDUSTRY PARTNERS, AND CORPORATE AND INDIVIDUAL DONATIONS. HHRI CONSISTENTLY RANKS NATIONALLY IN THE TOP 10% OF INSTITUTIONS RECEIVING FUNDING FROM THE NATIONAL INSTITUTES OF HEALTH (NIH). HHRI RESEARCHERS ARE EXPERTS IN THEIR FIELDS TACKLING OUR BIGGEST HEALTHCARE CHALLENGES, INCLUDING HIV/AIDS, SUBSTANCE USE DISORDERS, LIFE-THREATENING AND TIME-SENSITIVE CONDITIONS, CHRONIC DISEASES, AND ACCESS TO CARE. THEY CONDUCT BASIC, TRANSLATIONAL, CLINICAL, AND EPIDEMIOLOGIC RESEARCH WITH A FOCUS ON ACUTE CARE/TRAUMA, ADDICTION, HEALTH SERVICES, AND INFECTIOUS DISEASES. IN 2024, HHRI RESEARCHERS MADE SIGNIFICANT CONTRIBUTIONS TO THE STUDY AND PRACTICE OF MEDICINE IN THE FOLLOWING SPECIALTIES: ACUTE CARE/TRAUMA - CARDIAC BIOMARKERS - CARDIOPULMONARY RESUSCITATION - EMERGENCY MEDICINE - FROSTBITE AND BURN - INFECTIOUS DISEASES / SEPSIS - NEUROSURGERY - ORTHOPAEDICS - PULMONARY AND CRITICAL CARE MEDICINE - TRAUMA AND CRITICAL CARE - TRAUMA AND SURGICAL CRITICAL CARE - TRAUMATIC BRAIN INJURY (TBI) - TBI AND CORTICAL SPREADING DEPOLARIZATION (CSD) ADDICTION - ADDICTION MEDICINE - OPIOID TREATMENT RESEARCH - REDUCING THE IMPACT OF TOBACCO-RELATED DISEASES - TOBACCO CESSATION / BEHAVIOR HEALTH - TOBACCO TREATMENT RESEARCH HEALTH SERVICES - BRAIN HEALTH AND CEREBROVASCULAR CARE - CLINICAL OUTCOMES RESEARCH - CANCER - CHILDREN'S ISSUES - CHRONIC DISEASES - DEMENTIA AND AGING - DIABETES AND OBESITY - HEALTH, HOMELESSNESS, AND CRIMINAL JUSTICE - KIDNEY DISEASE - NEPHROLOGY, TRANSPLANTATION AND HEALTH DISPARITIES AND PHARMACOGENOMICS - NEUROLOGY, ALS, AND NEUROPALLIATIVE CARE - ORGAN TRANSPLANTATION INFECTIOUS DISEASES - COVID-19 - HIV / AIDS - HEPATITIS B AND C - IMMUNE THERAPY AND IMMUNOLOGY - MALARIA IMMUNOLOGY - SEXUALLY TRANSMITTED INFECTIONS, HIV PREVENTION THE MAJORITY OF OUR RESEARCH PROJECTS ARE TRANSLATIONAL IN NATURE. TRANSLATIONAL RESEARCH SEEKS TO TAKE DISCOVERIES MADE IN A LABORATORY SETTING AND TRANSLATE THEM INTO THERAPIES PHYSICIANS CAN USE IN THEIR MEDICAL PRACTICES TO IMPROVE THE LIVES OF PATIENTS LOCALLY AND AROUND THE GLOBE. IN AN ENVIRONMENT THAT EMPHASIZES PATIENT CARE, RESEARCH AND TEACHING, HHRI IS AT THE FOREFRONT OF DISCOVERING SOLUTIONS TO SOME OF THE MOST COMPLEX MEDICAL PROBLEMS. THE WORK OF OUR INVESTIGATORS IS ADVANCING MEDICINE TO ENSURE A HEALTHIER TOMORROW FOR ALL MEMBERS OF OUR COMMUNITY. FOR MORE INFORMATION ABOUT HHRI VISIT OUR WEBSITE AT WWW.HHRINSTITUTE.ORG.
Source: Form 990 for the year ending December 31, 2024, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Legitimacy checks
Is it registered with the IRS? Passed.
Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.
Has the IRS revoked its tax-exempt status? Passed.
Not on the IRS automatic revocation list.
Source: Automatic revocation of exemption list, Internal Revenue Service, file dated October 13, 2026.
Are donations tax-deductible? Passed.
On the IRS list of organizations eligible to receive tax-deductible contributions.
Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated October 13, 2026.
Is it keeping up with its IRS filings? Passed.
Most recent return on file covers the year ending December 2024.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.
How long has it been tax-exempt? Passed.
Recognized by the IRS since December 1990.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated October 13, 2026.
Is it in good standing with state regulators? Passed.
Not on California's list of charities barred from soliciting. Other states are not yet checked.
Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated October 21, 2026.
Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.