Stanley Manne Childrens Research Institute
Public records show a registered, tax-exempt organization in good standing.
What it says it does
SEE SCHEDULE O.
- Income
- $65.1 million
- Spending
- $73.1 million
- Spent on programs
- 57%
- Reserves
- -0.7 months of spending
- Largest source of income
- donations and private grants, 98%
- Employees
- 0
- Volunteers
- 10
- Highest pay
- $2.6 million, ex-officio dir/president & ceo lch
Source: Form 990 for the year ending August 31, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Financial health
Weak: 47 out of 100. Higher than 20% of charities in its peer group (medical research, $10m to $100m).
Reserves
0 of 35Spendable reserves are negative: it owes or has committed more than it holds.
Debt
20 of 20It owes 4% of what it owns.
Living within its means
4 of 15Spending exceeded income by 12% of income.
Income trend
15 of 15Income rose 3% on the year before.
Spending floor
8 of 1557% of spending went to programs and raising each dollar of donations cost 0 cents.
Source: Form 990 for the year ending August 31, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Governance
Strong: 95 out of 100. Higher than 37% of charities in its peer group (medical research, $10m to $100m).
Independent board
25 of 2510 of 12 voting board members are independent.
Conflict of interest policy
15 of 15Has a written conflict of interest policy.
Whistleblower policy
8 of 8Has a written whistleblower policy.
Record keeping policy
7 of 7Has a written policy on keeping and destroying records.
Board minutes
5 of 5Keeps minutes of board meetings.
Board sees the tax return
10 of 10Gave the board a copy of this return before filing it.
Pay set independently
0 of 5Reports no independent review process for its chief executive's pay.
Independent check of accounts
15 of 15Its accounts were audited by an independent accountant.
No reported misuse
10 of 10Reports no diversion of assets, excess benefits or loans to insiders.
Source: Form 990 for the year ending August 31, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Impact evidence
Describes programs. Its tax return describes what it does but we have found no measurable results in it.
Programs described in its return (1)
- $41.5 million spent. The mission of Stanley Manne Children's Research Institute ("Manne Research Institute"), an affiliate of Ann & Robert H. Lurie Children's Hospital of Chicago ("Lurie Children's"), is to generate new knowledge and translate advancements in the prevention, diagnosis and treatment of diseases that affect children's health through adolescence and adulthood. Manne Research Institute's multidisciplinary teams are committed to making discoveries that will improve the lives of children and their families. Manne Research Institute faculty members investigate a range of children's health and diseases across the translational science spectrum. Manne Research Institute's studies are led by over 750 researchers and staff and are organized into four scientific pillars: basic and preclinical science, clinical and community trials; community, population health, and outcomes; and quantitative science. Researchers and staff include physicians, scientists, postdocs, coordinators, statisticians, data analysts, trainees, and others who share their expertise. The pediatricians and scientists routinely collaborate with Lurie Children's academic partner, Northwestern University, and other medical centers and academic institutions across the globe, as well as with community partners such as schools and governments. Manne Research Institute receives external funding annually for research from the National Institutes of Health (NIH), other federal agencies, foundations, pharmaceutical, and biomedical companies. It is one of the nation's premier institutes for pediatric research, investing more dollars and resources in pediatric research than any other area hospital. In addition to the clinical and population health research facilities, Manne Research Institute has approximately 125,000 square feet of state-of-the-art laboratory space. The Research Institute's wet-lab research is located in the Louis A. Simpson & Kimberly K. Querrey Biomedical Research building on Northwestern University's Chicago campus. The building includes wet bench laboratories, animal facilities, and conference, educational, office, and collaborative space. Manne Research Institute Pillars Basic and Preclinical Science Basic and preclinical science researchers at Manne Research Institute conduct laboratory experiments that investigate essential functions of biological processes and the fundamental mechanisms of diseases and disorders affecting children's health. By closing gaps in scientific knowledge, basic and preclinical science researchers provide the foundation to develop next-generation technologies and treatments for pediatric patients. The basic and preclinical science pillar laboratory-based programs are organized into virtual scientific neighborhoods promoting collaborations between investigators, staff, and trainees. These neighborhoods include: * Developmental biology * Engineered solutions for health * Fertility and hormone preservation and restoration * Host-microbial interactions, inflammation, and immunity * Human molecular genetics and physiology * Immune deviation and disease * Injury, repair, and regeneration * Molecular and translational cancer biology * Neurobiology * Perinatal origins of disease Clinical and Community Trials Clinical and Community trials researchers at Manne Research Institute translate the meaningful discoveries of basic science into promising clinical applications through evaluation of new diagnostic tests and drugs, behavioral treatments, and other interventions to determine their effects on pediatric health. Multidisciplinary teams of researchers collaborate to study complex childhood health issues in areas such as critical care, oncology, neurology, transplant medicine, and neonatology. Their research generates innovation in the diagnoses, treatment, and prevention of diseases and disorders in the pediatric population. Community, Population Health, and Outcomes Community, population health, and outcomes researchers at Manne Research Institute seek to improve health, health care delivery, and access to care for children and youth from a broad range of backgrounds and environments. These research leaders advance our knowledge about the natural history, biological, psychological, social, behavioral, and environmental causes and influencers of common and prominent child health problems. Their research informs action for patients, families, communities, health system leaders, and policymakers. Much of their program evaluation work is conducted in partnership with community-based organizations as evidence is translated into clinical and public health interventions. Quantitative Science Quantitative science experts collaborate with researchers across Manne Research Institute to provide cutting-edge statistical and analytical support and computational techniques to maximize research impact and improve the health outcomes of pediatric patients. Their expertise in statistics, bioinformatics, database analytics, applied clinical informatics, and predictive analytics enables researchers to test hypotheses, answer research questions, and pursue understanding of behaviors across different populations. Research Strategy Mission-aligned, engaging, impactful strategic areas * Advanced therapeutics: End-to-end diagnostic development with early-stage trials for children and individualized therapy. * Health@Home: Innovative healthcare delivery and technology solutions outside traditional models. * Fertility and Hormone Preservation: early life fertility preservation, biology, and technology. * Perinatal Origins of Disease: Basic, translational, clinical practice and public health research for determinants of early life health trajectories. * Healthy Brain: The basis of and approaches to mental, behavioral, and neurological health. * Global Health Collaboration: Foster international collaborations to address global health disparities. The mission of Stanley Manne Children's Research Institute ("Manne Research Institute"
Source: Form 990 for the year ending August 31, 2025, filed with the Internal Revenue Service. Rating method 2026.2. How we rate
Legitimacy checks
Is it registered with the IRS? Passed.
Listed in the IRS master file of tax-exempt organizations as a 501(c)(3) charitable organization.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.
Has the IRS revoked its tax-exempt status? Passed.
Not on the IRS automatic revocation list.
Source: Automatic revocation of exemption list, Internal Revenue Service, file dated September 30, 2026.
Are donations tax-deductible? Passed.
On the IRS list of organizations eligible to receive tax-deductible contributions.
Source: Publication 78 data: organizations eligible for tax-deductible contributions, Internal Revenue Service, file dated September 10, 2026.
Is it keeping up with its IRS filings? Passed.
Most recent return on file covers the year ending August 2025.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.
How long has it been tax-exempt? Passed.
Recognized by the IRS since May 1987.
Source: Exempt Organizations Business Master File, Internal Revenue Service, file dated September 7, 2026.
Is it in good standing with state regulators? Passed.
Not on California's list of charities barred from soliciting. Other states are not yet checked.
Source: May Not Operate or Solicit for Charitable Purposes list, California Attorney General, Registry of Charities and Fundraisers, file dated October 7, 2026.
Ratings and checks are our reading of public records, using the published method. They are not a statement about anyone's honesty. If you work for this organization, you can send corrections or results, confirm you want gifts through Veridonate, or ask to be removed from giving.